UVR8 — Lactuca sativa

Summary

LsUVR8, the garden lettuce (Lactuca sativa) UVR8 gene on chromosome 5, encodes a protein with an RCC1/BLIP-II domain and a regulator of chromosome condensation domain. The product is annotated with DNA binding transcription factor activity, protein homodimerization activity, chromatin binding, and ubiquitin ligase activity, and is associated with DNA methylation-dependent heterochromatin assembly, epigenetic regulation of gene expression, and positive regulation of auxin-mediated signaling. LsUVR8 is linked to UV-B light response, photomorphogenesis, anthocyanin and flavonoid metabolism, pigmentation, and photoperiodic flowering. It is also associated with yield, shoot fresh weight, leaf growth and development, root mass density, and UV light sensitivity. The protein localizes to the nucleus, chromatin, plastid, and the Cul4-RING E3 ubiquitin ligase complex. Studies of related genes in other species connect the family to UV-B perception, photomorphogenic development, pathogen resistance, and seed oil content.