HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C500245050 on lettuce chromosome 5, is a P-type ATPase with heavy-metal-associated domains and annotated copper, zinc, cadmium, potassium, and sodium transporter activities. In lettuce, it is associated with detoxification of zinc, copper, and cadmium ions, copper and iron ion membrane transport, response to cobalt and toxic substances, regulation of root morphogenesis, and peptidyl-lysine methylation. The gene product has been linked to traits including copper sensitivity, drought tolerance, high temperature stress response, oxidative stress response, bacterial disease response, leaf morphology, root development, plant height, flowering time, germination rate, and stomatal opening and closure. Studies of related genes in other species connect the family to copper transport, photosynthesis under high light, zinc detoxification, and cadmium translocation and detoxification.