HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C500258540 on lettuce chromosome 5, is a P-type ATPase with heavy-metal-associated domains. The product is annotated with copper, zinc, and cadmium transporter activities, as well as histone methylase activity. In lettuce, LsHMA1 is associated with detoxification of copper, zinc, and cadmium ions, metal ion homeostasis, and responses to cobalt and toxic substances. It is linked to proton export across the plasma membrane, cell pH regulation, and root morphogenesis. The gene has been connected to numerous agronomic traits, including drought tolerance, disease tolerance, plant height, leaf morphology and senescence, flowering time, germination rate, root length, stomatal opening, and responses to high temperature, oxidative stress, and bacterial disease. Studies of related genes in other species link the HMA family to copper transport, chloroplast copper delivery, photosensitivity, ethylene receptor biogenesis, and heavy metal tolerance.