HMA1 — Lactuca sativa

Summary

LsHMA1, encoded by the gene LSAT_V11C400220060 on lettuce chromosome 4, is a P-type ATPase of the IB subfamily with transmembrane transporter activity. It is annotated for P-type monovalent and divalent copper transporter activity, cadmium-exporting ATPase activity, and P-type zinc transporter activity, and it binds copper, ATP, and other metals. The protein localises to the vacuolar membrane, plasma membrane, and general membrane. LsHMA1 is associated with copper ion detoxification and homeostasis, response to toxic substances, cadmium transport, and membrane transport. It has also been linked to root length and plant height. Studies of related genes in other species connect the family to heavy metal transport and detoxification, though these functions are not yet established for LsHMA1 itself.