M2 — Lactuca sativa

Summary

LsM2, located on chromosome 4 of garden lettuce (Lactuca sativa), encodes a protein with a cyclophilin-type PPIase domain and tetratricopeptide repeat (TPR) domains. The gene product is associated with molecular functions including cis-trans proline isomerase activity, salicylic acid binding, and peroxidase activity, and is linked to biological processes such as sesquiterpenoid metabolism, protein proline isomerization, and alternative mRNA splicing. LsM2 is associated with traits including variegated leaf, heterosis, photosynthetic rate, respiration rate, temperature stress response, herbicide sensitivity, and root hair length. It is also associated with phenotypes like heat stress tolerance, pathogen defense, and disease resistance. Studies of related genes in other species link the cyclophilin family to drought response, cold stress tolerance, hydrotropism, and embryo patterning.