F3H — Lactuca sativa

Summary

LsF3H (LSAT_V11C400172720) on chromosome 4 of garden lettuce encodes a 2-oxoglutarate-dependent dioxygenase with flavanone 3-dioxygenase, flavonol synthase, and chalcone isomerase activities. The gene is associated with anthocyanin, flavonoid, coumarin, and sucrose biosynthesis, as well as pigment accumulation, photomorphogenesis, and responses to UV-B, cold, auxin, fungal molecules, and oomycetes. It has been linked to leaf color, anthocyanin and flavonoid content, chlorophyll content, shoot fresh and dry weight, quantum yield, stomatal resistance, and oxidative stress response. Associations also include powdery mildew resistance, pollen viability and thermotolerance, lateral root and root hair formation, cold acclimation, and circadian clock regulation. The protein localizes to the cytosol, nucleus, endoplasmic reticulum, and tonoplast. Studies of related genes in other species connect the family to seed coat pigmentation, UV-B tolerance, and flavonol and glucosinolate biosynthesis.