RUG3 — Lactuca sativa

Summary

LsRUG3, also known as UVR8, encodes a protein with an RCC1/BLIP-II domain and a regulator of chromosome condensation domain. The gene is associated with protein binding and has been linked to mitochondrial complex I assembly, RNA splicing, photomorphogenesis, pigmentation, and the transition from vegetative to reproductive phase. It is associated with responses to stress, MMS, and downregulation of abscisic acid-mediated signaling. Localisation evidence places the product in the cytoplasm, mitochondria, and Golgi complex. Associations with agronomically relevant traits include shoot fresh weight, photosynthetic rate, stomatal resistance, and anthocyanin content. Phenotypic associations involve DNA damage response, mitochondrial function, root growth, reactive oxygen species accumulation, and ABA sensitivity. Studies of related genes in other species link the family to mitochondrial complex I biogenesis.