M2 — Lactuca sativa

Summary

LsM2, located on chromosome 4 of garden lettuce (Lactuca sativa), encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) and is annotated with multiple molecular functions including cis-trans proline isomerase activity, salicylic acid binding, and peroxidase activity. The gene is associated with a wide range of biological processes such as sesquiterpenoid metabolism, protein proline isomerization, alternative mRNA splicing, and responses to chlorate and sulfate starvation. It has been linked to numerous traits including variegated leaf, heterosis, photosynthetic rate, sucrose content, root hair length, and responses to temperature stress, light intensity, and herbicides. Additionally, LsM2 is connected to phenotypes such as heat stress tolerance, disease resistance, auxin transport, and embryo patterning. Studies of related genes in other species link the cyclophilin family to drought response, cold stress tolerance, hydrotropism, and phototropism.