PMIT1 — Lactuca sativa

Summary

LsPMIT1, located on chromosome 4 of garden lettuce (Lactuca sativa), encodes a member of the NRAMP family of metal ion transporters. The gene product exhibits transmembrane transporter activity for manganese, iron, cadmium, and aluminium ions. LsPMIT1 is associated with manganese, iron, and cadmium ion homeostasis and transport, as well as responses to manganese starvation and iron. It localises to endosome, vacuolar, and Golgi membranes, the plasmalemma, and plastids. The gene is linked to photosynthetic rate, plant height, and root length. Associations with phenotypes include growth under manganese deficiency, cadmium transport, iron remobilization, seed germination, and photosystem II activity. Studies of related genes in other species link the family to iron mobilization, manganese homeostasis, pathogen resistance, and cadmium tolerance.