FLS — Lactuca sativa

Summary

LsDLO1 (FLS, LsDMR6, LsGA20OX2) on chromosome 4 of garden lettuce encodes a 2-oxoglutarate-dependent dioxygenase with flavonol synthase, flavanone 3-dioxygenase, 4-coumaroyl 2'-hydroxylase, thebaine 6-O-demethylase, and methyltransferase activities. The gene is associated with secondary metabolite biosynthesis, including coumarin, morphine, phenylpropanoid, and flavonoid anabolism, as well as cellular response to starvation, response to fungi and fungal molecules, seed germination, and response to cold. It has been linked to flavonoid content, leaf senescence, and guanidine production. The protein localises to the cytosol and cytoplasm. Studies of related genes in other species connect the family to susceptibility to Tobacco rattle virus, while broader sequence similarity links the family to traits such as leaf chlorophyll content, fruit weight, stem elongation, transpiration rate, and protein content.