CUM1 — Lactuca sativa

Summary

LsCUM1 (LSAT_V11C400168020) on chromosome 4 of garden lettuce encodes a translation initiation factor 4E family protein with RNA m7G cap binding, translation initiation factor activity, and also annotated with linoleate 13S-lipoxygenase and salicylic acid binding activities. The gene is associated with responses to viruses, fungi, bacteria, herbivores, wounding, jasmonic acid, and UV-B light, as well as with green leaf volatile biosynthesis, lipid oxidation, jasmonic acid anabolism, photoperiodic flowering, and regulation of defense and translation. It has been linked to traits including aphid and insect damage response, disease tolerance, stem and leaf senescence, root hair length and thickness, stomatal closure time, and salt tolerance. The protein localizes to the cytosol, plastid, chloroplast thylakoid membrane and envelope, P bodies, stress granules, and nucleolus. Studies of related genes in other species connect the family to virus resistance, translation initiation, and abiotic stress tolerance.