M2 — Lactuca sativa

Summary

LsM2 (LSAT_V11C300113610) on chromosome 3 of garden lettuce encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase) with cyclosporin A binding activity. The gene is associated with protein folding and the regulation of protein refolding, as well as sesquiterpenoid metabolism, lactone anabolism, and sporopollenin biosynthesis. It is linked to responses to abscisic acid, salt, and mannitol, and to activation of the salinity response. The product localises to the chloroplast stroma, cytosol, plasma membrane, cytoplasm, and nucleus. The gene is also linked to heterosis. Related genes in other species connect the family to peptidyl-prolyl cis-trans isomerase activity (EC 5.2.1.8).