BIP — Hordeum vulgare subsp. vulgare

Summary

HORVU.MOREX.R3.6HG0545620 (symbol BIP, also known as HvHSP70-12 or HvBIP) on barley chromosome 6H encodes a member of the Hsp70 family of ATP-dependent protein folding chaperones, containing the characteristic BIP_NBD and HSP70_peptide-bd domains. The gene is associated with the cellular response to unfolded protein, ER stress response, and protein refolding, as well as with ERAD pathway, protein storage, and root hair tip growth. It has been linked to numerous agronomic traits including temperature stress response, osmotic sensitivity, root hair length, photosynthetic rate, stomatal resistance, leaf senescence, flowering time, disease tolerance, and seed growth and development. The gene is also connected to male fertility, thermotolerance, virus resistance, and gravitropism. Studies of related genes in other species link the family to cadmium stress tolerance, stress acclimation, and seed storage protein accumulation.