VAM2 — Cucumis melo

Summary

CmVAM2 (MELO3C004827.2) on melon chromosome 13 encodes a protein membrane adaptor belonging to the VPS41 family, characterized by Znf_RING_Vps41, beta-propeller, TPR, clathrin/VPS repeat, and WD40 repeat domains. The gene is associated with cucumber mosaic virus resistance in melon, as well as vacuolar transport, vacuole fusion, vegetative growth, and geotropism. It is linked to endosome vesicle fusion, macroautophagy, cellular response to starvation, and vacuolar protein sorting, and localizes to the HOPS complex, clathrin-coated vesicles, late endosomes, vacuolar membrane, tonoplast, endosomes, extracellular space, and nucleus. Associations with photosynthetic rate have also been noted. Studies of related genes in other species link the family to pollen tube-stigma interaction, male transmission, post-Golgi trafficking, zinc uptake, and copper transport.