CYP — Camelina sativa

Summary

CsCYP18-1 (CSA17G002430) encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase; EC 5.2.1.8) with a Cyclophilin_A-like domain, possessing cis-trans proline isomerase activity and binding to U5 and U2 snRNA, cyclosporin A, and proteins. In Camelina sativa, this gene is associated with protein folding, regulation of protein refolding, mRNA splicing via the spliceosome, detoxification, and responses to abscisic acid, heat, salt, and mannitol. It localises to the cytosol, nucleus, nucleolus, chloroplast stroma, plasmalemma, stress granules, and the catalytic step 2 spliceosome. The gene has been connected to heat stress tolerance and pre-mRNA splicing. Studies of related genes in other species link the family to high temperature stress response.