KCS2 — Camelina sativa

Summary

CsKCS2 (CSA17G007380) on Camelina sativa chromosome 17 encodes a 3-ketoacyl-CoA synthase, a member of the FAE1-type polyketide synthase family with thiolase-like and ACP synthase III domains, and exhibits multiple enzyme activities including trihydroxystilbene synthase, acetoacetyl-CoA reductase, trans-2-enoyl-CoA reductase, ketoreductase, 3-hydroxyacyl-CoA dehydratase, and protein tyrosine phosphatase activities. The gene is associated with very-long-chain fatty acid metabolism, cutin-based cuticle development, suberin biosynthesis, wax anabolism, sphingolipid metabolism, polyketide anabolism, trichome papilla formation and branching, polar cell growth, osmotic and wounding responses, pollen development, and regulation of cell division. It localizes to the endoplasmic reticulum membrane, fatty acid elongase complex, mitochondria, cytosol, and nucleus. CsKCS2 is linked to drought and salt tolerance, root morphology and thickness, male sterility, leaf composition, and cell elongation traits. Studies of related genes in other species connect the family to cuticular wax formation, pollen fertility, root hair elongation, and very-long-chain fatty acid composition.