DML1 — Brassica oleracea var. botrytis

Summary

BoDML1 (BOLND125_C04P012910.1_BOLND125_V1) on cauliflower chromosome 4 encodes a protein with domains including DME/ROS1, RRM_DME, HhH-GPD, and DNA glycosylase, and is annotated with cytosine C-5 DNA demethylase activity, AP lyase activity, and other molecular functions. The gene is associated with active DNA demethylation via the direct 5-methylcytosine excision pathway, base excision repair, and epigenetic regulation of gene expression. It has been linked to seed viability, flowering time, disease tolerance, salt tolerance, root morphology, meristem and embryo development, and oxidative stress response. The product localises to the nucleus, nucleolus, RNA polymerase IV and V complexes, and plasmodesmata. Studies of related genes in other species connect the family to salt and cold stress tolerance, antiviral defence, DNA methylation patterning, and transgenerational insect resistance.