BRCA1 — Brassica oleracea var. botrytis

Summary

BoBRCA1, on cauliflower chromosome 1, encodes a protein with RING-finger, BRCT, PPR and DYW domains characteristic of the BRCA1 family. The product possesses ubiquitin-protein transferase activity and binds DNA, RNA, pre-rRNA, mRNA, zinc and identical proteins. It is associated with homologous recombination, DNA repair, genome stability and integrity, and the cellular response to gamma radiation. Associations also include macroautophagy, autophagy, regulation of meristem organisation, leaf development, shoot apical meristem development, root mass density, quiescent centre maintenance, cadmium stress response, geminivirus resistance, and abnormal meristem development with inhibited root growth. The protein localises to the nucleus, cytoplasm, chloroplast stroma and mitochondria. Studies of related genes in other species link the family to DNA double-strand break repair, DNA crosslink repair, shoot apical meristem organisation and dehydration stress tolerance.