NHX8 — Brachypodium distachyon

Summary

BRADI_4G17381V3 (NHX8, also known as SOS1) on chromosome 4 of Brachypodium distachyon encodes a member of the cation/H⁺ exchanger CPA1 family, with domains including a cyclic nucleotide-binding domain and RmlC-like jellyroll fold. The protein exhibits lithium:proton antiporter, sodium:hydrogen exchanger, potassium:proton antiporter, NAD ADP-ribosyltransferase, and protein kinase activities, and binds proteins. It is associated with vacuolar membrane, tonoplast, chloroplast envelope, plasmalemma, cytoplasm, and nucleus. The gene is linked to lithium export, sodium import, cell pH regulation, response to superoxide, hydrogen peroxide, and ozone, nitric oxide anabolism, lateral root morphogenesis, virus-induced PTGS, ethylene and jasmonic acid signaling, and activation of salinity response. Traits associated with NHX8 include sodium uptake, yield, photosynthetic rate, stomatal resistance, root development, plant height, drought tolerance, and disease tolerance. Related genes in other species link the family to sodium ion homeostasis, high-salinity stress tolerance, and potassium uptake.