CAM2 — Brachypodium distachyon

Summary

BdCAM2 (CAM2) on Brachypodium distachyon chromosome 1 encodes a protein containing EF-hand calcium-binding domains and is associated with diverse molecular functions including cyclosporin A binding, P-type calcium transporter activity, monoatomic ion channel activity, and MAPKK activity. The gene is associated with calcium ion homeostasis in the cytosol, calcium membrane transport, positive regulation of anthocyanin metabolism, cellular detoxification, and regulation of defense response by callose deposition. It localizes to the tonoplast, endosome membrane, nuclear envelope, and microtubules. BdCAM2 is associated with numerous traits including bacterial blight disease resistance, spikelet fertility, submergence tolerance, cadmium concentration, phosphorus uptake, water stress response, root system morphology, shoot growth angle, and vegetative-to-reproductive phase transition. Studies of related genes in other species link the family to immunity, freezing tolerance, salt stress tolerance, and photomorphogenesis.