HSP70 — Brachypodium distachyon

Summary

BRADI_1G66527V3 (HSP70) on chromosome 1 of Brachypodium distachyon encodes a heat shock protein 70, an ATP-dependent protein folding chaperone with ATP hydrolase activity and heat shock protein binding capability. The gene is associated with protein refolding, heat acclimation, response to heat and stress, the ERAD pathway, and the unfolded protein response in the endoplasmic reticulum. It has also been linked to auxin transport and signaling, basipetal auxin transport, amino acid membrane transport, virus-induced post-transcriptional gene silencing, and response to virus. The encoded protein localises to the ER lumen and chaperone complex, cytoplasm, nucleus, chloroplast membrane, tonoplast, and axonemal central pair projection. Additionally, this gene is linked to spikelet number. Studies of related genes in other species further connect the family to protein folding and stress responses.