DND1 — Arabidopsis thaliana

Summary

AT5G15410 (DND1, also known as AtCNGC2) encodes a protein with intracellular cAMP-activated cation channel activity, calmodulin binding, and cyclic nucleotide binding domains. This membrane-localized protein is associated with calcium ion import, programmed cell death induction, and macroautophagy. In Arabidopsis, DND1 is linked to disease resistance, including clubroot resistance, as well as heat stress tolerance, thermal sensing, and defense responses. The gene has been connected to floral transition, jasmonic acid signaling, auxin content, brassinosteroid sensitivity, stomatal resistance, leaf and stem senescence, and flowering time traits. Studies of related genes in other species associate the DND1 family with resistance to powdery mildew, Botrytis cinerea, and Phytophthora infestans, as well as with plant growth and ion transport.