EFR — Arabidopsis thaliana

Summary

AT5G20480, also known as EFR (EF-Tu receptor), encodes a leucine-rich repeat receptor-like serine/threonine kinase in Arabidopsis thaliana chromosome 5. The protein possesses transmembrane receptor protein kinase activity, protein serine/threonine kinase activity, and NAD(P)H oxidase H2O2-forming activity, and localizes to the plasma membrane, endomembrane system, and endosome. EFR is associated with detection of bacteria, immune response-regulating signaling pathways, pattern-triggered immunity, and reactive oxygen species production. The gene is linked to bacterial disease resistance, including against blight, wilt, and spot, as well as to Agrobacterium-mediated transformation susceptibility, nonhost resistance, and systemic signaling. Associations also extend to grain yield, leaf rolling, submergence tolerance, calcium concentration, phototropism, and jasmonic acid sensitivity. Studies of related genes in tomato link the family to weakened hypersensitive response and reduced reactive oxygen production during bacterial infection.