IRE1 — Arabidopsis thaliana

Summary

AT5G24360 (IRE1, IRE1B) in Arabidopsis thaliana encodes a protein with protein serine/threonine kinase activity (EC 2.7.11.1) and RNA endonuclease activity (EC 3.1.26.-), localising to the endoplasmic reticulum membrane. IRE1B is associated with the ER-nuclear signalling pathway, mRNA splicing via endonucleolytic cleavage, and the unfolded protein response. The gene has been linked to stress tolerance, including endoplasmic reticulum stress, salt tolerance, and virus resistance, as well as to cell death, autophagy in response to ER stress, and immune system processes. Associations with auxin response, root growth, cell elongation, vegetative growth time, and organogenesis have also been observed. Related genes in other species are linked to protein-folding homeostasis, autophosphorylation, and bacterial immunity.