APG5 — Arabidopsis thaliana

Summary

AT5G17290, also known as APG5 or ATG5 in thale-cress (Arabidopsis thaliana) on chromosome 5, encodes a protein containing the ATG5_UblA and ATG5_HBR domains, characteristic of the autophagy-related ATG5 family. The gene is associated with numerous autophagy-related processes, including macroautophagy, mitophagy, pexophagy, ER-phagy, and lipophagy, as well as broader catabolic processes such as heme a breakdown, rRNA breakdown, and GABA biosynthesis. It is also linked to mitochondrial protein import, OXPHOS, tetrapyrrole anabolism, and protein storage. The encoded product localizes to the cytoplasm. Associations with agronomically relevant traits include harvest index, submergence tolerance, chlorophyll content, seed maturation, stomatal opening, and self-incompatibility. Phenotypic associations include impaired growth, late flowering, enhanced senescence under short-day conditions, and early senescence with high reactive oxygen species accumulation.