FLC — Arabidopsis thaliana

Summary

AT5G10140 (FLC) in Arabidopsis thaliana encodes a MADS-box transcription factor, also known as FLOWERING LOCUS C or AGL25. The protein contains MADS-box and K-box domains and is annotated with sequence-specific DNA binding, transcription regulatory region binding, and protein dimerization activities. FLC is associated with the regulation of flowering time, vernalization response, and floral transition, as well as with traits including stem branching, plant height, biomass yield, seed germination, and seed protein content. It is also linked to circadian period, leaf area index, nitrate content, abscisic acid content, and responses to salt stress and pathogens. The gene localizes to the nucleus and is associated with the Mediator complex. Studies of related genes in other species link the family to seed weight, fruit size, and disease resistance.