AT4G02570 — Arabidopsis thaliana

Summary

AT4G02570 (AXR6/AtCUL1) encodes cullin-1, a core scaffold of the SCF (SKP1-CUL1-F-box) ubiquitin ligase complex. The protein possesses NEDD8 transferase activity, ubiquitin-like protein transferase activity, auxin receptor activity, and binds auxin, phosphatidate, and inositol hexakisphosphate. In Arabidopsis, CUL1 is associated with protein degradation, SCF complex formation, plant fertility, protein neddylation and deneddylation, COP9 signalosome assembly, male germ cell proliferation, positive regulation of organ growth, floral organ formation, and negative regulation of cellulose anabolism. It localises to CRL and ubiquitin ligase complexes, the CSN, and condensed nuclear chromosomes. The gene is linked to numerous traits including tiller bud dormancy, inflorescence size and height, leaf area index, seedling vigor, branch angle, petal number, root shape, and responses to far-red light and parasitic weeds. Related genes in other species are associated with spikelet number and wheat Fusarium head blight response.