EED3 — Arabidopsis thaliana

Summary

AT4G03550 (GSL5, also known as EED3 and PMR4) encodes a callose synthase (EC 2.4.1.34) with callose synthase activity, transglycosidase activity, and mRNA binding, belonging to the FKS1-like and Glyco_trans_48 domain families. The gene is associated with disease resistance, particularly powdery mildew resistance, and basal defense responses. It is linked to callose deposition at the cell plate, plasmodesmata, and phloem sieve plates, as well as exosome biogenesis, glucan anabolism, and defense response by callose deposition. The encoded protein localizes to the plasma membrane, cell plate, plasmodesma, and 1,3-beta-glucan synthase complex. GSL5 is also associated with traits including starch mobilization, phosphorus uptake, aphid response, light intensity response, cell elongation, and hypocotyl morphology. Studies of related genes in other species link the family to drought tolerance, bacterial disease response, and pollen fertility.