GAPC2 — Arabidopsis thaliana

Summary

AT1G13440, also known as GAPC2, encodes a glyceraldehyde-3-phosphate dehydrogenase C2, a protein with glyceraldehyde-3-phosphate dehydrogenase (NADP) activity and annotated with additional molecular functions including fructose-bisphosphate aldolase, phospholipase D, and voltage-gated anion channel activity. In Arabidopsis, GAPC2 is associated with the glycolytic pathway and seedling growth, and has been linked to a wide range of biological processes including redox signal response, S-nitrosylation, phosphatidic acid metabolism, TOR signaling, and aerobic respiration. The gene product localizes to multiple cellular compartments such as the plasma membrane, mitochondria, chloroplast envelope, vacuole, and nucleolus. GAPC2 is associated with numerous traits including grain yield, seed size, starch and sugar content, photosynthetic rate, drought and salinity tolerance, freezing tolerance, and stress responses. Studies of related genes in other species link the family to grain yield, thermotolerance, and disease resistance.