TPL (AT1G15750) — Arabidopsis thaliana

Summary

AT1G15750 (TPL, TOPLESS) encodes a protein with DNA-binding transcription repressor activity, histone demethylase and methylase activities, and protein-binding bridging function. It contains LisH, CTLH_C, and WD40 repeat domains characteristic of the TOPLESS family. TPL is associated with regulation of developmental vegetative growth, multicellular organism growth, apical cell fate commitment, ground tissue patterning, simple leaf morphogenesis, and fruit septum development. It localizes to chromatin silencing complexes, PRC2, HDAC, and SWI-SNF complexes. The gene is linked to numerous agronomic traits including seed shattering, seed volume and shape, tiller angle, stem strength, freezing stress response, drought recovery, salinity tolerance, copper and potassium content, in vitro regeneration ability, and floury endosperm. TPL also associates with anther dehiscence, flavonol biosynthesis, and responses to boron starvation and nitrite.