MYCGR3G99279 — Zymoseptoria tritici

Summary

LCB2 (MYCGR3G99279) on chromosome 2 of Zymoseptoria tritici encodes a protein with serine C-palmitoyltransferase and 5-aminolevulinate synthase activities, and binds pyridoxal phosphate. The product belongs to the aminotransferase class-II and pyridoxal phosphate-dependent transferase families. LCB2 is associated with sphingolipid, ceramide, and sphingosine anabolism, as well as protoporphyrinogen IX and heme anabolism, and with upregulation of organelle assembly and cell death. The protein localises to the endoplasmic reticulum, mitochondria, and mitochondrial lumen, and is membrane-associated. Studies of related genes in other species link the family to the serine palmitoyltransferase complex.