MYCGR3G100089 — Zymoseptoria tritici

Summary

MYCGR3G100089, also known as PKS1 or PKS3, encodes a polyketide synthase on Zymoseptoria tritici chromosome 5. The product possesses lovastatin nonaketide synthase, fatty acid synthase, ketoacyl-ACP synthase, SAM-dependent methyltransferase, and redox activities, along with phosphopantetheine and zinc binding. It contains multiple polyketide synthase domains including ketoacyl synthase, dehydratase, ketoreductase, acyl transferase, and phosphopantetheine-binding regions. The gene is associated with DHN-melanin biosynthesis, polyketide and secondary metabolite biosynthesis, lactone and lysine anabolism, melanin and fatty acid anabolism, ergosterol anabolism, and methylation. Studies of related genes in other species link the family to diverse secondary metabolite pathways.