IRT1 — Triticum turgidum subsp. durum

Summary

TRITD4AV1G201030 (symbol IRT1, also known as TtIRT1) on durum wheat chromosome 4A encodes a ZIP family metal transporter with transmembrane transporter activity for copper, zinc, manganese, iron, and cadmium ions. The gene is associated with zinc accumulation in durum wheat and has been linked to iron homeostasis, metal uptake, cadmium detoxification and accumulation, iron and zinc deficiency tolerance, chlorophyll content, photosynthetic efficiency, biomass production, grain filling period, and disease resistance. It is associated with processes including metal ion transport, cellular iron ion homeostasis, leaf senescence, response to bacteria, and cadmium transport. The protein localizes to the plasma membrane, endosome, late endosome membrane, and nucleus. Studies of related genes in other species link the family to iron acquisition, cadmium uptake, and nickel accumulation, as well as iron uptake and grain metal content.