IRT1 — Triticum turgidum subsp. durum

Summary

TRITD4AV1G230890, designated IRT1 (also known as TtIRT1, TtZIP3, and other synonyms) on durum wheat chromosome 4A, encodes a Fe(2+) transport protein 1 belonging to the ZIP family (Zn/Fe permease). The product exhibits transmembrane transporter activity for copper, zinc, manganese, iron, and cadmium ions, along with phosphoinositide and ubiquitin binding. IRT1 is associated with metal ion transport, cellular and multicellular iron homeostasis, nickel and cadmium transport, stress responses to zinc, leaf senescence, response to bacteria, and cellular response to hypoxia. It localizes to the plasma membrane, endosome, late endosome membrane, and ESCRT I complex. The gene is linked to grain filling period, plant growth and development, and salt tolerance. Associations include iron and zinc homeostasis, biomass production, cadmium detoxification, chlorophyll content, photosynthetic efficiency, root and leaf development, chloroplast development, and disease resistance.