ICDH — Triticum turgidum subsp. durum

Summary

TRITD3AV1G073920, designated ICDH or TtICDH on durum wheat chromosome 3A, encodes an isocitrate dehydrogenase (NADP(+)) belonging to the isocitrate dehydrogenase NADP domain family. The enzyme exhibits NADP and NAD isocitric dehydrogenase activity, along with ATP, copper, and magnesium binding. It is associated with the TCA cycle, glyoxylate cycle, NADPH regeneration, and NAD(P) metabolism, and has been linked to brassinosteroid-mediated signalling and defence responses to bacteria. The protein localises to chloroplast thylakoid and stroma, mitochondria, plastid, cytosol, and plasmodesmata. Associations with agronomic traits include proline content, salinity tolerance, photosynthetic rate, and root morphology. Studies of related genes in other species connect the family to drought tolerance, leaf relative water content, net photosynthetic rate, chlorophyll content, and disease tolerance.