CAM1 — Sorghum bicolor

Summary

SbCAM1, encoded by the sorghum gene SORBI_3001G309900 on chromosome 1, is a member of the major facilitator superfamily (MFS) and possesses multiple molecular functions including vitamin Bt transporter activity, S-nitrosoglutathione reductase (NADH) activity, carbohydrate transmembrane transporter activity, monoatomic ion channel activity, chaperone protein binding, SUMO transferase activity, and calcium ion binding. The gene is associated with diverse biological processes such as cadaverine transport, methanal metabolism, ERAD pathway, cellular responses to cold, salinity, and drought, lignin anabolism, protein folding, sumoylation, leaf senescence, heat acclimation, seed development, and programmed cell death. It localizes to chromatin, tonoplast, chloroplast envelope, plastid, mitochondria, and membrane. SbCAM1 is linked to traits including iron sensitivity, shoot branching, stomatal closure, photosynthetic rate, flowering time, disease tolerance, salt tolerance, root development, and abscisic acid sensitivity. Studies of related genes in other species connect the family to drought, salt, cold, and freezing tolerance, formaldehyde detoxification, and root development.