ADH — Sorghum bicolor

Summary

SORBI_3001G263900 (SbADH) encodes a protein with S-nitrosoglutathione reductase (NADH) activity, S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity, aldo-keto reductase (NAD) activity, redox activity, calcium ion binding, protein homodimerization activity, zinc binding, and protein binding, containing ADH-like and NAD(P)-binding domains. The gene is associated with responses to hypoxia, flooding, hydrogen peroxide, and heat acclimation, as well as seed development, programmed cell death, and cellular respiration. It has been linked to traits including stem thickness, plant height, photosynthetic rate, leaf senescence, drought tolerance, herbicide sensitivity, and low temperature stress response. Phenotypic associations include submergence, waterlogging, and hypoxia tolerance, aldehyde detoxification, fermentation, cold stress tolerance, and salt stress response. The protein localizes to plastids, mitochondria, cytosol, and nucleus. Studies of related genes in other species link the family to hypoxic stress response, freezing tolerance, and drought resistance.