ICDH — Solanum tuberosum

Summary

PGSC0003DMG400032124 (ICDH) on potato chromosome 1 encodes a protein with isocitrate/isopropylmalate dehydrogenase domains and NADP isocitric dehydrogenase activity (EC 1.1.1.42), and is annotated with NAD and NADP isocitric dehydrogenase, NAD, ATP, copper, and magnesium binding activities, and protein homodimerization activity. The gene is associated with NADPH regeneration, the glyoxylate cycle, oxidative phosphorylation, the pentose-phosphate shunt, and carbohydrate, sucrose, and cell wall polysaccharide metabolism. It has been linked to cytoplasmic male sterility, starch, sugar, glucose, and protein content, seed weight, photosynthetic and respiration rates, salt response, root morphology, and nitrogen metabolism. The encoded protein localizes to chloroplasts (thylakoid and stroma), mitochondria, plastids, cytosol, apoplast, and plasmodesmata. Studies of related genes in other species connect the family to drought tolerance, disease tolerance, chlorophyll content, and oxidative stress response.