ALS — Solanum tuberosum

Summary

PGSC0003DMG400034102, designated ALS (also known as AHAS, StALS, StTZP5, StCSR1, StIMR1, and TZP5) on potato chromosome 3, encodes an acetolactate synthase, a thiamine pyrophosphate-dependent enzyme. The protein possesses acetolactate synthase activity, pyruvate decarboxylase activity, and 2-hydroxyacyl-CoA lyase activity, binds TPP, FAD, and magnesium, and localises to the chloroplast stroma as part of the acetolactate synthase complex. This gene is associated with branched-chain amino acid, valine, and fatty acid anabolism, as well as response to herbicide, CRISPR-Cas system components, NHEJ, HDR, and regeneration. It has been linked to herbicide tolerance, particularly through the G121A variant, and to cellulose content. Studies of related genes in other species connect the family to imidazolinone and sulfonylurea herbicide sensitivity and resistance, water use efficiency, root length, chlorophyll content, and plant growth.