HSP70 — Solanum tuberosum

Summary

PGSC0003DMG400027611, symbol HSP70 and preferred name StHSP70-6 on potato chromosome 11, encodes a heat shock protein 70 family member with ATP hydrolase activity, ATP binding, heat shock protein binding and protein folding chaperone functions. The gene is associated with protein folding in the endoplasmic reticulum, the ERAD pathway, the unfolded protein response, and protein refolding. It has been linked to sterol anabolism, fatty acid anabolism, sucrose metabolism, lipid metabolism, iron-sulfur cluster assembly, nucleosome assembly, detoxification, nitric oxide storage, chlorophyll fluorescence, immune response, virus-induced post-transcriptional gene silencing, pollen germination and pollen tube growth. Phenotypically, StHSP70-6 is associated with PVY susceptibility. Associations with proline content, net photosynthetic rate and photosynthetic rate have also been recorded. The protein localises to the ER lumen, chloroplast stroma, mitochondria, cytoplasm, nucleus and membrane. Studies of related genes in other species link the family to mitochondrial heat shock 70 kDa proteins and BiP chaperones.