HMG1 — Solanum tuberosum

Summary

PGSC0003DMG400013663, designated StHMG1 on potato chromosome 2, encodes a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34), the enzyme that catalyses the rate-limiting step of the mevalonate pathway. The product contains the characteristic HMG_CoA_Rdtase domains and is annotated to protein binding. In potato, StHMG1 is associated with steroidal glycoalkaloid content, and the gene has been linked to terpenoid metabolism, plant height, flower morphology and colour, flowering time, male fertility, senescence, and defence and wound responses. Associations also include protein content, photosynthetic rate, biomass, and seed phytosterol content. The protein localises to plastid, peroxisome, mitochondrial, chloroplast and ER membranes, and the nucleus, and is associated with systemic acquired resistance, jasmonic acid response, and isoprenoid, sterol, triterpenoid and saponin biosynthesis.