HMG1 — Solanum tuberosum
Summary
PGSC0003DMG400003461, designated HMG1 (also known as HMG2, StHMGR1, StHMGR2, and MAD3) on potato chromosome 2, encodes a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34), an enzyme of the mevalonate pathway. The product contains the HMG_CoA_Rdtase domain and is localised to the endoplasmic reticulum and peroxisome membranes. In potato, HMG1 is associated with steroidal glycoalkaloid content, and the gene has been linked to terpenoid and sterol biosynthesis, plant height, biomass, flowering time, male fertility, senescence, wound healing, pathogen and herbivore defence, and photosynthetic rate. Annotated biological processes include isoprenoid, cholesterol, triterpenoid and saponin metabolism, as well as pigmentation and regulation of growth. Studies of related genes in other species link the family to mevalonate pathway regulation, phytosterol content and disease resistance.
Annotations
- Chromosome
- 2
- Related genes
- HMG1, HMG2
- GO terms
- Wound Healing, protein synthesis, NO storage, regulation of isoprenoid metabolism, cholesterol anabolism, secondary metabolism, terpene anabolism, Chloroplast Membrane
- Publications
- 9245257, 20865301, 12198192, 11114204, 21601648, 26015445, 23572922, 20736450
- Traits
- mevalonate pathway regulation, isoprenoid biosynthesis, mevalonate synthesis, enzyme activity regulation, light response, Reduced Sterol and Triterpenoid Levels, Root Elongation Inhibition, Dwarf, Sterile, Rapid Leaf Senescence, plant development