HPR3 — Pisum sativum

Summary

PSAT4G150720 (HPR3, also known as PDE1) on chromosome 4LG4 encodes a glyoxylate reductase (NADP(+)) with multiple annotated enzyme activities including glycerate dehydrogenase (NAD+), hydroxypyruvate reductase, and D-lactate dehydrogenase (NAD+). The protein contains a D-isomer-specific 2-hydroxyacid dehydrogenase catalytic domain and NAD(P)-binding domain. HPR3 is associated with photorespiration, the oxidative photosynthetic carbon pathway, formate breakdown, and glucose and lipid metabolism. It localizes to mitochondria, cytosol, and chloroplasts. The gene has been connected to phosphate-deficiency tolerance, photorespiratory flux, plant growth, and photochemical efficiency. Studies of related genes in other species link the family to 4-hydroxyphenyllactic acid accumulation and impaired tyrosine conversion. Additional associations include viral life cycle, fat cell differentiation, and negative regulation of cellular response to phosphate starvation.