HPR3 — Pisum sativum

Summary

PSAT4G150800 (HPR3) on garden pea chromosome 4LG4 encodes a D-isomer-specific 2-hydroxyacid dehydrogenase with NAD(P)-binding domains, annotated with glycerate dehydrogenase, hydroxypyruvate reductase, glyoxylate reductase and D-lactate dehydrogenase activities. The gene is associated with photorespiration and the oxidative photosynthetic carbon pathway, and its product localises to the chloroplast and cytosol. HPR3 has been linked to photorespiratory flux, plant growth, photochemical efficiency and phosphate-deficiency tolerance. Additional associations include glucose homeostasis, lipid metabolism, fatty acid oxidation, lipogenesis, lipolysis, fat cell differentiation, digestion, viral life cycle, and negative regulation of cellular response to phosphate starvation. Studies of related genes in other species link the family to 4-hydroxyphenyllactic acid accumulation and impaired tyrosine conversion.