HPR3 — Pisum sativum

Summary

PSAT4G150760 (HPR3) on chromosome 4LG4 encodes a D-isomer-specific 2-hydroxyacid dehydrogenase with NAD(P)-binding domains, annotated with glycerate dehydrogenase, hydroxypyruvate reductase, glyoxylate reductase, and D-lactate dehydrogenase activities. The gene is associated with photorespiration, the oxidative photosynthetic carbon pathway, formate breakdown, and lipid metabolism, and localises to mitochondria and cytosol. HPR3 has been linked to photorespiratory flux, photochemical efficiency, plant growth, and phosphate-deficiency tolerance. It is also associated with glucose homeostasis, fat cell differentiation, viral life cycle, and negative regulation of cellular response to phosphate starvation. Related genes in other species are linked to 4-hydroxyphenyllactic acid accumulation and impaired tyrosine conversion.