FOX — Phaseolus vulgaris

Summary

PvFOX (PHAVU_002G221800) on chromosome 2 of French bean encodes a berberine bridge enzyme (BBE) family protein with FAD-binding and oxidoreductase domains, annotated with cannabidiolate synthase, delta9-tetrahydrocannabinolate synthase, and tetrahydroberberine oxidase activities, as well as FAD binding and redox activity. The gene is associated with cannabinoid and terpenoid anabolism, alkaloid metabolism, protein secretion, cellular response to hypoxia, and defence response to bacteria. Its product localises to vesicles, vacuole, apoplast, plant-type cell wall, endoplasmic reticulum, and cytoplasm. PvFOX is also linked to ethylene sensitivity. Studies of related genes in other species connect the family to seed maturation and dormancy traits, as well as climatic adaptation phenotypes.