PI3K — Phaseolus vulgaris

Summary

PHAVU_002G070100, designated PvPI3K or PvVPS34, encodes a phosphatidylinositol 3-kinase of the class III/VPS34 type, containing PI3K catalytic and accessory domains, a C2 domain, and annotated with protein serine/threonine kinase activity, ATP binding, and protein complex binding. In French bean, this gene is associated with phosphatidylinositol 3-phosphate biosynthesis, autophagy, pexophagy, macroautophagy, TOR signaling, late endosome-to-vacuole transport, microgametogenesis, DNA damage checkpoint, and phosphoinositide-mediated signaling. It localizes to class III PI3K complexes, the TOR complex, endosome membrane, and the Golgi. Associations with root nodule number, pollen germination and development, leaf senescence, salt stress response, heat stress recovery, root hair growth, and proline accumulation have been noted. Studies of related genes in other species link the family to plant growth and development, disease resistance, and stomatal closure.