GCN2 — Nicotiana attenuata

Summary

A4A49_27938 (GCN2) on chromosome 9 of coyote tobacco (Nicotiana attenuata) encodes a protein with histidine-tRNA ligase activity and protein serine/threonine kinase activity (EC 2.7.11.1), containing a HisRS-like core, anticodon-binding domain, and a protein kinase domain. The gene is associated with histidyl-tRNA aminoacylation, mitochondrial translation, translation initiation, and protein synthesis. It is linked to abscisic acid (ABA) signaling and anabolism, stomatal closure, seed germination, cortical microtubule organization, response to cadmium, and signal transduction. Associations with agronomic traits include drought tolerance, leaf relative water content, stomatal opening, chlorophyll content, and abscisic acid content. The encoded protein localizes to the cytosol, mitochondria, and cortical microtubules. Studies of related genes in other species link the family to stress signaling.