AGO1 — Nicotiana attenuata

Summary

A4A49_28535 (AGO1) on chromosome 9 of coyote tobacco (Nicotiana attenuata) encodes an Argonaute-family protein with RNA endonuclease activity and nucleic acid/RNA binding, containing Piwi and RNaseH-like domains. The gene is associated with RNA-dependent gene silencing, RNA processing, regulation of gene expression, and antiviral and cellular responses to virus. It is linked to meiotic processes including upregulation of meiotic DNA double-strand break formation, male and female meiotic nuclear division, microgametogenesis, megagametogenesis, and syngamy. Additional associations include stem cell population maintenance, leaf development, cell cycle and division, signal transduction, response to jasmonic acid, and chlorophyll breakdown. The protein localises to the nucleus, nucleolus, NOR, and cytoplasm. The gene is also associated with calcium concentration and chlorophyll content. Related genes in other species include AGO18, which is linked to reproductive development.