GCN2 — Nicotiana attenuata

Summary

A4A49_27940 (GCN2) in coyote tobacco (Nicotiana attenuata) on chromosome 9 encodes a eukaryotic translation initiation factor 2alpha kinase with ATP and tRNA binding activities, containing protein kinase and RWD domains. The gene is associated with regulation of cytoplasmic translational initiation in response to stress, cellular response to amino acid starvation, peptidyl-serine phosphorylation, abscisic acid anabolism and signaling, stomatal closure, and response to herbicide and cadmium. It is linked to drought tolerance, leaf relative water content, abscisic acid content, and stomatal opening. GCN2 is associated with sulfonylurea herbicide tolerance, glyphosate sensitivity and tolerance, UV-B and light stress responses, oxidative stress, immune response, photosynthesis inhibition, cadmium and salt tolerance, cold tolerance, DNA damage response, nutrient sensing, translation rate, and plant growth. Studies of related genes in other species link the family to defense against herbivory, abscisic acid homeostasis, stomatal immunity, seed germination, and amino acid deprivation tolerance.